Tropicana Field is located directly east of interstate 275 in St. Petersburg. I-275 is the main interstate highway that runs north and south through Clearwater and St. Petersburg. Tampa International Airport feeds directly onto I-275. The dome is visible from the highway. I-375 and I-175 both veer off of interstate 275 and feed into Tropicana Field. Follow the signs for parking.

-From Tampa (north): Take I-275 South and follow the signs to Exit 22
-From St. Petersburg (south): Take 1-275 North to Exit 22 and follow the signs.
-From points North and East: South on I-275 to Exit 22. To avoid traffic, take Exit #24, travel east on 22nd Ave. North and then south on 16th Street, Martin Luther King (9th Street), or 4th Street.
-From Clearwater/N. Pinellas: South on McMullen Booth Road or US 19, proceed East to I-275 south, or less congested alternatives of 16th Street, Martin Luther King (9th Street) or 4th Street.
-From points South: North on I-275 to Exit 22. To avoid traffic, take exit #19 to 22nd Ave. South and head North on 16th Street, Martin Luther King (9th Street), or 4th Street.
-From South Pinellas beaches: Take Treasure Island or Pasadena Ave. to 1st Ave. South or take the Pinellas Bayway to I-275 Northbound.